The Houston Astros (8-15) face the Cleveland Guardians (13-10) on Tuesday, April 21, 2026 at 6:10 PM ET on Regional Sports Network. TBD takes the mound against Parker Messick. Our model gives Cleveland Guardians a 76% edge.
Quick Facts
| Matchup | Houston Astros at Cleveland Guardians |
| Date | Tuesday, April 21, 2026 |
| First Pitch | 6:10 PM ET |
| Venue | Progressive Field |
| TV | Check local listings / MLB.TV |
| Streaming | MLB.TV |
| Probable Pitchers | TBD vs Parker Messick |
Where to Watch HOU vs CLE
The Houston Astros visit the Cleveland Guardians on Tuesday, April 21, 2026 with first pitch at 6:10 PM ET. The game will air on Regional Sports Network and can be streamed on MLB.TV.
Pitching Matchup
TBD takes the mound for the Houston Astros against Parker Messick for the Cleveland Guardians.
Matchup Analysis
The Houston Astros (8-15) have a 24% win probability in our model.
The Cleveland Guardians (13-10) are given a 76% chance with home field advantage.
Head-to-Head
Recent Form
Houston Astros — Last 5 Games
1-4 · Streak: L4L 5-7 vs St. Louis CardinalsApr 19
L 5-7 vs St. Louis CardinalsApr 18
L 4-9 vs St. Louis CardinalsApr 18
L 2-3 vs Colorado RockiesApr 17
W 3-1 vs Colorado RockiesApr 16
Cleveland Guardians — Last 5 Games
3-2 · Streak: W2W 8-4 vs Baltimore OriolesApr 19
W 4-2 vs Baltimore OriolesApr 18
L 4-6 vs Baltimore OriolesApr 17
W 4-2 vs Baltimore OriolesApr 16
L 3-5 @ St. Louis CardinalsApr 15
See live scores: MLB Scores