The Houston Astros (9-15) face the Cleveland Guardians (13-11) on Tuesday, April 21, 2026 at 6:10 PM ET on Regional Sports Network. Ryan Weiss takes the mound against Parker Messick. Our model gives Cleveland Guardians a 71% edge.
Quick Facts
| Matchup | Houston Astros at Cleveland Guardians |
| Date | Tuesday, April 21, 2026 |
| First Pitch | 6:10 PM ET |
| Venue | Progressive Field |
| TV | Check local listings / MLB.TV |
| Streaming | MLB.TV |
| Probable Pitchers | Ryan Weiss vs Parker Messick |
Where to Watch HOU vs CLE
The Houston Astros visit the Cleveland Guardians on Tuesday, April 21, 2026 with first pitch at 6:10 PM ET. The game will air on Regional Sports Network and can be streamed on MLB.TV.
Pitching Matchup
Ryan Weiss takes the mound for the Houston Astros against Parker Messick for the Cleveland Guardians.
Matchup Analysis
The Houston Astros (9-15) have a 29% win probability in our model.
The Cleveland Guardians (13-11) are given a 71% chance with home field advantage.
Head-to-Head
Season Series
HOU leads 1-0W 9-2 @ CLE (Apr 20)
Recent Form
Houston Astros — Last 5 Games
1-4 · Streak: W1W 9-2 @ Cleveland GuardiansApr 20
L 5-7 vs St. Louis CardinalsApr 19
L 5-7 vs St. Louis CardinalsApr 18
L 4-9 vs St. Louis CardinalsApr 18
L 2-3 vs Colorado RockiesApr 17
Cleveland Guardians — Last 5 Games
3-2 · Streak: L1L 2-9 vs Houston AstrosApr 20
W 8-4 vs Baltimore OriolesApr 19
W 4-2 vs Baltimore OriolesApr 18
L 4-6 vs Baltimore OriolesApr 17
W 4-2 vs Baltimore OriolesApr 16
See live scores: MLB Scores