In the 2025 NFL draft, the Chargers hold the 22nd pick for their first selection, presenting a challenge in projecting their choice. Among the realistic first-round targets for Los Angeles are Michigan DT Kenneth Grant and Oregon DT Derrick Harmon. Grant, with ties to the Chargers staff, could address the team's need for a impact defensive tackle, while Harmon offers pass-rushing skills lacking in the current lineup.
Another potential pick is Michigan TE Colston Loveland, a popular mock draft selection for the Chargers. Loveland, recruited by Jim Harbaugh, could bolster the team's tight end position for the long term. North Carolina RB Omarion Hampton emerges as a suitable choice if both defensive tackles and Loveland are off the board, providing the Chargers with a strong fit for their offense and backfield longevity alongside Najee Harris.