Lyon will see the return of Malick Fofana to the matchday squad against Manchester United after missing the first leg due to injury. However, Fofana is unlikely to start in the UEFA Europa League quarter-final. Ernest Nuamah is the only notable absentee for Lyon, out with a knee injury following surgery. Georges Mikautadze is set to replace Alexandre Lacazette in the forward position, with Thiago Almada and Rayan Cherki on the wings. Corentin Tolisso is expected to play in the No.10 role, while Nemanja Matić is likely to start against his former club. The predicted Lyon XI includes Lucas Perri; Nicolas Tagliafico, Moussa Niakhaté, Clinton Mata, Ainsley Maitland-Niles; Jordan Veretout; Nemanja Matić; Thiago Almada, Corentin Tolisso, Rayan Cherki; and Georges Mikautadze.